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Co-Authors
- C. P. Suryawanshi
- V. R. Patil
- R. Y. Chaudhari
- S. D. Firake
- R. B. Pimprikar
- M. D. Patil
- S. B. Yeshwante
- D. S. Saindanem
- D. T. Gautam
- C. R. Tenpe
- A. G. Sheikh
- V. S. Mohod
- A. P. Kulkarni
- A. R. Juvekar
- R. T. Kakade
- M. Tabrej
- S. D. Firke
- V. N. Sayankar
- P. B. Suruse
- N. J. Duragkar
- A. Gundawar
- S. M. Sarode
- M. A. Chaudhari
- G. Vidyasagar
- G. S. Talele
- G. Vidya Sagar
- P. K. Nimase
- B. M. Firke
- P. D. Warke
- D. S. Saindane
- A. S. Kulkarn
- A. N. Sagri
- R. V. Keny
- S. B. Yashwante
- S. K. Mandlik
- Mujawar Tabrej
- M. P. Patil
- K. P. Bhusari
- Y. A. Chaudhari
- S. V. Chordiya
- Tanvir Shaikh
- P. N. Patil
- A. R. Bendale
- M. Mittal
- M. A. Chaudhri
- B. Shrivastava
- R. W. Lohe
- P. R. Barethiya
- A. V. Kasture
- S. W. Lohe
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Kale, M. K.
- Antiparkinsonian Effect of Cassia tora on Oxotremorine Induced Parkinson Methodology
Abstract Views :369 |
PDF Views:0
Authors
C. P. Suryawanshi
1,
V. R. Patil
1,
R. Y. Chaudhari
1,
M. K. Kale
2,
S. D. Firake
2,
R. B. Pimprikar
3,
M. D. Patil
3,
S. B. Yeshwante
3,
D. S. Saindanem
3
Affiliations
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 1 (2009), Pagination: 35-38Abstract
The Parkinson's disease is mainly distinguished from other diseases based on the key feature that is tremors. Oxotremorine induced oxidative stress is implicated as a common pathway in development of Parkinson's symptoms like, tremor, salivation and temperature variation. Hence Oxotremorine-induced tremor model was used to evaluate antiparkinsonian drugs. Different extracts of plant of Cassia tora such as, petroleum ether (200mg/kg) p.o., methanolic (200mg/kg) p.o. and ethyl acetate extract (200mg/Kg) p.o. were used to investigate antiparkinsonian effect on oxotremorine induced Parkinson's symptoms in mice. Procyclidine, an anticholinergic, antiparkinsonian drug was administered as a standard drug at a dose of 5mg/kg p.o., 1hr prior the administration of oxotremorine (0.5mg/kg) S.C. Methanolic extract at 200mg/kg p.o route of administration decreased (p<0.05) Parkinson's symptoms, while petroleum ether extract (200mg/kg)p.o and ethyl acetate extract (200mg/kg)p.o shows moderate action. This study suggests that cassia tora is a plant with possible therapeutic value for Parkinson's disease.Keywords
Parkinson's Disease, Oxotremorine, Tremor, Procyclidine.
References
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- Zhenbao J, Tao F, Guo L, Guanjun T and Xiaolin D, Antioxidant properties of extracts From juemingzi (Cassia tora L.) evaluated in vitro.LWT.2007; 40: 1072-1077
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- Yang SF, Wu Q, Sun AS, Huang XN and Shi JS, Protective Effect and Mechanism of Ginkgo Biloba Leaf Extracts for Parkinson Disease induce by 1-methyl-4-phenyl- 1, 2, 3, 6- tetrahydropyridine. Acta Pharmacol.2001; 12: 1089-93.
- Choi J S, Lee HJ and Park KY, In vitro Antimutagenic effect of Anthraquinone aglycone and napthopyrone glycosides from Cassia tora. Planta Medica.1997; 63: 11-14
- Kim YM, Lee CH, and Kim H G, Anthraquinones isolated from cassia tora seeds show an antifungal property against phytopathogenic fungi. J. Agri. Food Chem. 2004; 52: 6096- 6100
- Patil UK, Saraf S and Dixit VK, Hypolipidemic activity of seeds of cassia tora Linn. J. Ethnopharmacol. 2004; 90: 249-252
- Wu C H and Yen, GC, Antigenotoxic properties of cassia tora L: mechanism of action and the influence of roasting process. Life Science. 2004; 76: 85 -101
- Yang YC, Lim MC, and Lee HS, Emodin isolated from cassia tora shows larvicidal activity against three mosquito species. Agri. Food chem. 2003; 26: 7629- 31
- Chidume FC, Kwanashie HO and Wambebe C, Antinociceptive and muscle contracting activities of the methanolic extracts of cassia tora leaf. J. Ethnopharmacol.2002; 81: 205-209
- Vogel HG, Antiparkinsonism activity. In Drug Discovery and Evaluation, edited by Springer Verglag Berlin Heidelberg, New York. 2002; 2nd ed: pp 577-78.
- Yen GC, Duh PD and Chaung DY, Antioxidant activity of anthraquinones and anthrones. Food Chemistry. 2000; 70: 437-441
- Haematological Evaluation of Moringa pterygosperma Gaertn. Leaves Extract in Phenylhydrazine Induced Anaemia in Rats
Abstract Views :282 |
PDF Views:2
Authors
Affiliations
1 KYDSCT'S College of Pharmacy, Sakegaon, Tal. - Bhusawal, Dist. - Jalgaon 425 201(M.S.), IN
2 Institute of Pharmaceutical Education & Research, Borgaon (Meghe), Wardha - 442 001, IN
1 KYDSCT'S College of Pharmacy, Sakegaon, Tal. - Bhusawal, Dist. - Jalgaon 425 201(M.S.), IN
2 Institute of Pharmaceutical Education & Research, Borgaon (Meghe), Wardha - 442 001, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 6 (2010), Pagination: 392-396Abstract
The extracts of Moringa pterygosperma were tested against Phenylhydrazine induced anaemia in rats and the changes in different haematological parameters have been evaluated. It has been found that the extract of Moringa pterygosperma produces significant increase in haematological parameters particularly Hb content, RBC counts, Haematocrit, Plateletcrit etc.Keywords
Moringa pterygosperma Gaertn, Phenylhydrazine (PHZ), Red Blood Cell (RBC) Count, Haemoglobin (Hb).References
- Dhonde SM, Siraskar BD, Kulkarni AV, Kulkarni AS, Bingi SS. Haematinic Activity of Ethanolic Extract of Stem Bark of Bauhinia variegata Linn. Indian J of Green Pharmacy 2007; 1(3-4):28-32.
- Satyanarayana U, Chakrapani U. A text Book of Biochemistry. 2nd ed. Books and allied pvt. Ltd. Kolkata; 2002. p. 199-228.
- Diallo A, Gbeassor M, Vovor A, De Souza C. Effect of Tectona grandis on phenylhydrazine-induced anaemia in rats. Fitoterapia 2008; 79:332-336.
- Nadkarni KM. The Indian Materia Medica. 3rd ed. Bombay popular Prakashan; 1982 reprint 1993. p. 811-816.
- Jain, GC. Glossary of Indian herbs. Herbal Munish Plaza; 2005. p. 89,278.
- Chopra, RN, Nayar, SL. Supplement to Glossary of Indian Medicinal Plants. 3rd reprint; 1992. p. 71-170.
- WHO Drug Information. World Health Organization, Geneva. 2002; 16:2: p. 115.
- Wang, YM. Drug induced Hemolysis. J. Pharmacol 1977; 8:13-19.
- Gabriel A, Julius EO, Jeanne YN. Haematinic activity of Hibiscus cannabinus. African J of Biotechnology 2005; 4:833-837.
- Yakubu MT, Akanji MA, Oladiji AT. Haematological evaluation in male albino rats following chronic administration of aqueous extracts of Fadogia agrestis stem. PHCOG MAG 2007; 3:9:34-38.
- Kanase A, Patil S. Antianaemic properties of Ayurvedic drugs, raktavardhak, punarnavasav and navayas louh in albino rats during phenylhydrazine induced heamolytic anaemia. Indian J Exp Biol 2000; 38:253-257.
- Sarkar PK, Prajapati PK, Choudhary AK, Shukla VJ, Ravishankar B. Haematinic evaluation of Lauha Bhasma and Mandura Bhasma on HgCl2-Induced Anaemia in Rats. Indian J Pharm Sci 2008; 791-795.
- OECD Guideline for testing of chemicals, acute oral toxicity - fixed dose procedure. Organization for Economic Co-operation and development, Paris, December 2001;420.
- Criswell KA, Sulkanen AP, Hochbaum AF, Bleavins MR. Effects of Phenylhydrazine or Phlebotomy on Peripheral Blood, Bone Marrow and Erythropoietin in Wistar Rats. J of Applied Toxicol 2000; 20:25-34.
- Jain SK, Subrahmanyam D. On the Mechanism of Phenylhydrazine Induced Haemolytic anaemia. J of Biochemical and Biophysical Research Communication 197; 8:4:1320-1324.
- Berger J. Screening of toxic-haemolytic anaemia in laboratory rats: a model of phenylhydrazine induced haemolysis. J of Haematologia 1985; 18:3:193-200.
- Anti-Diarrheal Activity of Methanolic and Aqueous Extracts of Dillenia indica L
Abstract Views :212 |
PDF Views:0
Authors
S. B. Yeshwante
1,
A. R. Juvekar
1,
R. B. Pimprikar
2,
R. T. Kakade
2,
M. Tabrej
2,
M. K. Kale
3,
S. D. Firke
3
Affiliations
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 140-142Abstract
The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.Keywords
Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.References
- Wendel GH, Maria AOM, Guzman JA, Giordano O, Pelzer LE. Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana. Fitoterapia 2008; 79: 1-5.
- Kirtikar KR, Basu BD. Indian medicinal Plants. Lalit M. and Basu, Allahabed, India.1981.
- The wealth of India- A dictionary of Indian Raw Materials and Industrial Products, Volume-III, D-E. National institute of Science communication and information research, CSIR, New Delhi; 2003.
- Shome U, Khanna RK, Sharma HP. Pharmacognostic studies on Dillenia indica Linn. II-Fruit and Seed. Proc. Indian Acad. Sci. (Plant Sci.). 1980; 89:91-104.
- Shome U, Khanna RK, Sharma HP. Pharmacognostic studies on Dillenia indica Linn. I. leaf. Proc. Indian Acad. Sci. 1979; 88: 35-48.
- Banerji N, Majumder P, Dutta NL. A new pentacyclic triterpene lactone from Dillenia indica. Phytochemistry. 1975; 12: 1447-1448.
- Pavanasasivam G, Suktanbawa MU. Flavonoids of some Dilleniaceae species. Phytochemistry. 1975; 14: 1127-1128.
- Abdille MH, Singh RP, Jayaprakash GK, Jena BS. Antioxidant activity of the extracts from Dillenia indica fruits. Food chemistry. 2005; 90: 891-896.
- Yeshwante SB, Juvekar AR, Nagmoti DM, Wankhede SS, Shah AS, Pimprikar RB, Saindane DS. Anti-inflammatory activity of methanolic extract of Dillenia indica L. Leaves. J. Young. Pharmacists. 2009;1:63-66.
- Bhakuni DS, Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN. Screening of Indian plants for biological activity Pt. II. Ind J Exp bio. 1968; 7: 250-262.
- O.O. Adeyemi OO, Akindele AJ. Antidiarrhoeal activity of the ethyl acetate extract of Baphia nitida (Papilionaceae). J. Ethnopharmacol. 2008;116: 407-412.
- Rang HP, Dale MM, Ritter JM. Textbook of Pharmacology. UK: Churchill Livingstone; 1999
- Mukherjee PK, Saha K, Murugesan T, Mandal SC, Pal M, Saha BP. Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India. J. Ethnopharmacol. 1998;60:85-89
- Capasso F, Mascolo N, Izzo AA, Gaginella TS. Dissociation of castor oil-induced diarrhoea, and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester. Br. J. Pharmacol. 1994;113:1127-1130.
- Mbagwu HOC, Adeyemi OO. Anti-diarrhoeal activity of the aqueous extract of Mezoneuron benthamianum Baill (Caesalpiniaceae). J. Ethnopharmacol. 2008;116:16-20.
- To Study Implementation of Enterprise Resource Planning-Quality Management Module in Textile Industry
Abstract Views :193 |
PDF Views:0
Authors
V. N. Sayankar
1,
M. K. Kale
2
Affiliations
1 KYDSCT Institute of Management Science, Sakegaon, Ta. Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110, IN
1 KYDSCT Institute of Management Science, Sakegaon, Ta. Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441110, IN
Source
Research Journal of Engineering and Technology, Vol 3, No 3 (2012), Pagination: 207-210Abstract
Enterprise resource planning (ERP) systems integrate internal and external management information across the entire organization covering up finance, human resource, manufacturing, sales service etc. ERP systems automate these activities with an integrated software application. Their purpose is to facilitate the flow of information between all business functions inside the boundaries of the organization and manage the connections to outside stakeholders. In today's global market the customer buying behavior tremendously changed. Customers are now quality conscious and demand for the quality product. In order to produce quality product organizations are taking efforts by establishing good quality management system. Quality management is the comprehensive solution that supports the company throughout the product life cycle and along the supply chain. It offers a wide range of functions and collaborative services, which are fully integrated into ERP, for assuring and managing the quality of products and assets. It also focuses on prevention and continuous process improvement through collaboration and sustained quality control. Quality Management (QM) assures that products meet stringent regulatory standards, are safe and uniform, and meet company product specifications.Keywords
Business Functions, Quality Product, Process Improvement.- To Study Work Quality of Employees by Use of Computers in Textile Industry
Abstract Views :167 |
PDF Views:0
Authors
V. N. Sayankar
1,
M. K. Kale
2
Affiliations
1 KYDSCT, Institute of Management and Science, Sakegaon, Ta. Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road , Nagpur-441110, IN
1 KYDSCT, Institute of Management and Science, Sakegaon, Ta. Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road , Nagpur-441110, IN
Source
Research Journal of Engineering and Technology, Vol 2, No 4 (2011), Pagination: 223-226Abstract
To improve the quality of work life, job satisfaction, compensation, human relation, working condition, grievance, competency development, eliminate job stress and wellbeing, employers can also make efforts to be more aware of the workload and job demands. Employees often are able to give employers the best advice on reducing work stress. In today's high tech, fast-paced world, the work environment is very different than it was a generation ago. Industries need to find ways to attract, recruits, motivates, and retains its workforce. Today's organizations need to be more flexible so that they are equipped to develop their workforce and enjoy their commitment. Therefore, organizations are required to adopt a strategy to improve the employees' quality of work life to satisfy both the organizational objectives and employee needs. Companies are adopting the new technology viz use of computers in their department. The newer technology will find the time saving methods. Creative thing will increase the quality of quality control employee's by systematic quality management. The presentation is one of tools of forming the information in well-desired manner and in easily understandable format. The graphical presentation of data helps the quality control employee's of textile industry in understanding easily their work performance.Keywords
Use of Computers, Creativity, Quality of Work Life, Graphical Presentation of Data.- Formulation and Evaluation of Antidiabetic Herbal Capsules
Abstract Views :197 |
PDF Views:0
Authors
Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongari, Hingana Road, Nagpur- 441110 (M. S.), IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110 (MS), IN
1 Sharad Pawar College of Pharmacy, Wanadongari, Hingana Road, Nagpur- 441110 (M. S.), IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur-441 110 (MS), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 2 (2012), Pagination: 113-118Abstract
The work presented here deals with formulation and evaluation of herbal antidiabetic capsule containing dried extracts of Gymnema sylvestre, Mucuna prurience and Ginkgo biloba. Phytochemical screenings of all three extracts were performed and their purity was checked by TLC, HPTLC and also by gravimetric method. While formulating the capsules three batches were selected with different concentration of extracts of Gymnema sylvestre and same quantity of Mucuna prurience and Ginkgo biloba extracts. The antidiabetic activity of three formulations was performed on diabetic rats to find out the better activity than others. The formulation 3 has given the better result as compared to formulation 1 and 2. For the pharmacological evaluation, all the experiments were designed and conducted as per CPCSEA and IAEC guidelines. The single dose study of optimized formulation shows a significant decrease in serum glucose level at 2, 4, 6 and 24 h while comparing with only extract of Gymnema sylvestre and standard antidiabetic drug Glibenclamide. The optimized formulation showed much better result as compared to extract of Gymnema sylvestre. Physical and chemical evaluation of optimized formulation has been performed and compared the peaks of standard drug with extracts and formulation by HPTLC analysis.Keywords
Herbal Capsule, Antidiabetic Activity, Gymnema sylvestre, Mucuna prurience, Ginkgo biloba.- Preparation and Characterization of Self Emulsifying Drug Delivery System (SEDDS)
Abstract Views :161 |
PDF Views:0
Authors
Affiliations
1 C/O M. B. Sarode, Shanti Nagar, Plot no.6, Yawal road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
1 C/O M. B. Sarode, Shanti Nagar, Plot no.6, Yawal road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 4 (2010), Pagination: 290-294Abstract
A mixture of oil and surfactant (especially non-ionic) forms clear and transparent isotropic solution known as self-emulsifying system (SES). Lovastatin is HMG-CoA enzyme inhibitor. This enzyme is needed by the body to make cholesterol. Lovastatin causes cholesterol to be lost from LDL, but also reduces the concentration of circulating LDL (low density lipoprotein) particles. Animals studies demonstrated that lovastatin crosses the blood-brain and placental barriers. Elderly patients or those with renal insufficiency may have higher plasma concentrations of lovastatin after administration and may require a lower dose. SEDDS is prepared and filled in hard gelatin capsules. In vitro dissolution indicates that the release of lovastatin from SEDDS varied according to the type and ratio of the oil and surfactants. It was concluded that there was an increase in both the solubility and dissolution rate of drug in SEDDS form as compared to marketed tablet.Keywords
SEDDS, Enzymes.- Formulation and Evaluation of Antihypertensive Microparticulate Drug Delivery System
Abstract Views :188 |
PDF Views:0
Authors
Affiliations
1 C/O M. B. Sarode, Shanti Nagar, Plot No.6, Yawal Road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
3 J.Z.M.D.S. College of Pharmacy, Mamurabad, IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
1 C/O M. B. Sarode, Shanti Nagar, Plot No.6, Yawal Road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
3 J.Z.M.D.S. College of Pharmacy, Mamurabad, IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 3 (2010), Pagination: 237-240Abstract
The phenomenon of absorption via a limited part of the GI tract has been termed the "narrow absorption window", once the dosage form passes the absorption window, the drug will be neither bioavailable nor effective. In extreme cases, drugs, e.g. methyldopa, Captopril, that are insufficiently absorbed due to narrow absorption cannot be delivered entirely, and are either given by a parentral route, or the development of such medication, which is otherwise safe and effective, is stopped altogether. Diltiazem HCL is a calcium channel blocker widely used for the treatment of angina pectoris, arrhythmias and hypertension. Its short biological half life and thus frequent administration (usually three to four times a day) makes it a potential candidate for CR: SR preparations. It has a short plasma half life of about 3 hours. Diltiazem HCL microspheres were prepared by chemical cross linking method. The microspheres were spherical, discrete and free-flowing. Encapsulation efficiency was found to be 95.62 %. Diltiazem HCL release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres.Keywords
Microencapsulation, Controlled Release, Chitosan.- Preparation and Evaluation of Floating Calcium Alginate Beads of Clarithromycin
Abstract Views :185 |
PDF Views:0
Authors
S. M. Sarode
1,
G. Vidya Sagar
2,
M. K. Kale
3,
P. K. Nimase
4,
A. P. Kulkarni
3,
S. D. Firke
3,
B. M. Firke
3,
P. D. Warke
3,
M. A. Chaudhari
3
Affiliations
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN
1 C/O M. B. Sarode, Shanti nagar, Plot no.6, Yawal Road, Bhusawal (M.S.), IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Smt.S.S.Patil college of Pharmacy, Chopda (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 173-177Abstract
The objective of this investigation was to develop an intra gastric floating drug delivery system of clarithromycin and also attempts were made to sustain the release of clarithromycin. Multiple-unit floating beads of clarithromycin were prepared from sodium alginate solution containing Hydroxypropylmethylcellulose (K100M) and sunflower oil by using emulsion-gelation method. These beads were evaluated for entrapment efficiency, drug loading, buoyancy and in vitro drug release. All formulations were the floating lag time below two minutes and shows total floating duration more than ten hours. It was observed that entrapment efficiency, drug loading and buoyancy was greater with formulation containing two percent sodium alginate solution and five percent calcium chloride solution along with 500mg HPMC and five ml sunflower oil (i.e.F14) and also the result of in-vitro dissolution studies reveals that the formulation F14 gave sustained release pattern of clarithromycin upto 12 hrs.Keywords
Floating Alginate Beads, Emulsion Gelation, Clarithromycin, Controlled Release.- Formulation and Evaluation of Ethyl Cellulose Coated Microspheres of Aceclofenac
Abstract Views :172 |
PDF Views:0
Authors
Affiliations
1 C/O M. B. sarode, Shanti Nagar, Plot no.6, Yawal Road , Bhusawal (M.S.), IN
2 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
1 C/O M. B. sarode, Shanti Nagar, Plot no.6, Yawal Road , Bhusawal (M.S.), IN
2 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 41-43Abstract
The pain is symptomatic of some form of dysfunction and resultant inflammatory processes in the body. More than 15% of the worldwide population suffers for instance from some form of osteoarthritis and this incidence is even higher in elderly. As the world population is grows older, this incidence will continue to rise. Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities and due to its preferential cox-2 blockade it has better safety than conventional NSAIDs with respect to adverse effects on gastrointestinal and cardiovascular system. Ethyl cellulose microspheres of Aceclofenac were prepared by emulsion- solvent evaporation technique that is an industrially feasible technique. The microspheres are spherical, discrete and free-flowing. Encapsulation efficiency was found to be 81%. Aceclofenac release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres. These microspheres were found suitable for oral controlled release.
Keywords
Microencapsulation, Controlled Release, Aceclofenac.- Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188
Abstract Views :157 |
PDF Views:0
Authors
D. S. Saindane
1,
A. S. Kulkarn
2,
A. N. Sagri
2,
R. B. Pimprikar
3,
S. B. Yeshwante
3,
C. P. Suryawanshi
3,
S. D. Firke
4,
M. K. Kale
4
Affiliations
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN
1 Dept. of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
2 Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.), IN
3 Gangamai College of Pharmacy, Nagaon, Dhule, (M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 162-166Abstract
This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.Keywords
Cefixime, Solid Dispersion, Poloxamer 188, Freeze Drying, Dissolution Rate, Binary System.- Physicochemical Characterization of Solid Dispersion of Telmisartan with Alkaliser by Hot Melt Method
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Authors
M. D. Patil
1,
R. V. Keny
2,
R. B. Pimprikar
3,
S. B. Yashwante
3,
D. S. Saindane
3,
S. K. Mandlik
2,
Mujawar Tabrej
3,
M. K. Kale
4,
B. M. Firke
4
Affiliations
1 255- Shramsafalya, Niwas, Janta Park, Navapur, Dist. Nandurbar, MS, PIN- 425418, IN
2 Government College of Pharmacy, Goa, IN
3 Gangamai College of Pharmacy, Nagaon, Dhule(M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S.), IN
1 255- Shramsafalya, Niwas, Janta Park, Navapur, Dist. Nandurbar, MS, PIN- 425418, IN
2 Government College of Pharmacy, Goa, IN
3 Gangamai College of Pharmacy, Nagaon, Dhule(M.S.), IN
4 KYDSCT's College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 3 (2009), Pagination: 250-253Abstract
The effect of molecular weight of polyethylene glycols (PEGS) and drug/PEG ratio on the structure and dissolution rates of the solid dispersions with Telmisartan have been examined. Telmisartan (TEL) was chosen as a model drug due to its poor and pH dependent water solubility. The alkalizer used to modify the pH of TEL was NaOH, in the SD system significantly increased the drug dissolution rate in gastric fluid (pH 1.2) . Structural change in drug crystallinity to an amorphous form was also a contributing factor based on differential scanning calorimetry (DSC) thermograms and powder X-ray diffraction (PXRD) patterns. The drug frequency of the C=O band decreased and the O–H broad band in the Fourier transform infrared (FTIR) spectra disappeared when this alkalizer was added. It was evident that the alkalizer in PEG 6000 based SDs synergistically enhanced dissolution of TEL not only by modulating pH but also by changing drug crystallinity to an amorphous form via molecular interactions.Keywords
Telmisartan (TEL), Solid Dispersion (SD), Alkalizer, Hot Melt Method.- To Study the Reduction in Time for Use of Computers in Quality Control System
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Authors
V. N. Sayankar
1,
M. K. Kale
2
Affiliations
1 KYDSCT Institute of Management and Science, Sakegaon, Ta. Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur, IN
1 KYDSCT Institute of Management and Science, Sakegaon, Ta. Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur, IN
Source
Asian Journal of Management, Vol 2, No 3 (2011), Pagination: 94-97Abstract
A quality control system performs inspection, testing and analysis to ensure that the quality of the products is as per the laid down quality standards. In the globalised market to sustain the market pressure, quality plays an important role. Therefore to stay in competitive market the use of computer is utmost in quality control system for timely results for the improvement of quality of the product. The computer can selectively retrieve data into its main memory (RAM) from any peripheral device (terminal, disk, tape, etc.) connected to it.Keywords
Quality Control System, Inspection, Analysis, Quality Standards.- To Study Development of Management Information System of Computers for Use in Quality Control System in A Fabric Industry
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Authors
V. N. Sayankar
1,
M. K. Kale
2
Affiliations
1 KYDSCT Institute of Management and Science, Sakegaon, Ta.Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur, IN
1 KYDSCT Institute of Management and Science, Sakegaon, Ta.Bhusawal, Dist. Jalgaon 425201, IN
2 Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur, IN
Source
Asian Journal of Management, Vol 2, No 3 (2011), Pagination: 115-118Abstract
Every manufacturing organization is concerned with the quality of their products. While achieving the targeted production in scheduled time it is important that the finished product meet established standard specifications, so as to satisfy customer needs regarding its quality and services. Information or any feedback becomes an important source for quality improvement. Earlier, the information system purely depended on the typewriter and hand written memos, records and sending this information was cumbersome and searching or reproducing them was time consuming job. With the advent of computers the specified information management system has been developed to improve quality and services.Keywords
Quality, Specifications, information System.- Evaluation of Ginkgo biloba in Diabetic Nephrotoxicity
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Authors
Affiliations
1 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur 441110, IN
2 Tapi Valley’s, College of Pharmacy, Faizpur, Ta. Yawal , Dist. Jalgaon (MS), IN
3 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441110, IN
1 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur 441110, IN
2 Tapi Valley’s, College of Pharmacy, Faizpur, Ta. Yawal , Dist. Jalgaon (MS), IN
3 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441110, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 6 (2011), Pagination: 286-288Abstract
Nephrotoxicity is the major cause of morbidity and mortality in diabetes and it is the leading cause of end stage renal disease. Hyperglycemia induced oxygen free radicals cause oxidative stress and subsequent oxidative damages, leading cell and tissue injury. Sprague-Dawley rats of both sexes were divided into 4 groups, Control, Diabetic control , Diabetic + Ginkgo biloba and Diabetic + Vit E group . Blood urea, serum creatinine and serum uric acid as well as plasma malondialdehyde, superoxide dismutase, catalase, reduced glutathione were estimated and histopathological studies of kidneys were performed. Alloxan at the dose of 120mg/kg i.p, for 2 months at the interval of 14 days, induced diabetes. This prolonged diabetes increased oxidative stress and caused an increase in the levels of serum creatinine, urea, uric acid and plasma malondialdehyde while there were decrease in the levels of superoxide dismutase, catalase and reduced glutathione in diabetic group as compared to normal control group. Histopathological examination revealed hemorrhage, necrosis, and infiltration of leukocytes around the glomerulus and interstitial spaces. Co-administration of Ginkgo biloba 300mg/kg orally, daily for 2 months in diabetic-induced rats caused decreased in the levels of serum creatinine, urea, uric acid and plasma malondialdehyde. Increased levels of superoxide dismutase, catalase and reduced glutathione were also found. The study revealed protective antioxidant activity of Ginkgo biloba in diabetic nephrotoxicity.
Keywords
Diabetes, Oxidative Stress, Nephrotoxicity, Ginkgo biloba.- Antimicrobial Studies on Selected Medicinal Plants in Khandesh Region, Maharashtra, India
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Authors
Affiliations
1 Gandhi Chowk, Savda, Dist-Jalgaon, IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
3 TVES’S Hon’ble L. M. C. College of Pharmacy, Faizpur, IN
4 Department of Pharmacology, K.Y.D.S.C.T’s College of Pharmacy, Sakegaon- 425201, IN
1 Gandhi Chowk, Savda, Dist-Jalgaon, IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
3 TVES’S Hon’ble L. M. C. College of Pharmacy, Faizpur, IN
4 Department of Pharmacology, K.Y.D.S.C.T’s College of Pharmacy, Sakegaon- 425201, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 5 (2010), Pagination: 386-390Abstract
Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. Now we are turned in to medicinal plant analysis of active compounds and conservation aspect. In the present study we had select the four important medicinal plants in the Khandesh region. Such plants are widely used in this region for ayurvedic purpose by villagers and local herbal health masters. We have colleted four medicinally important medicinal plants such as Acalypha indica, Cassia auriculata, Eclipta alba and Phyllanthus niruri for antimicrobial studies. The experiment carried out in the selected medicinal plants leaves and ischolar_mains. The results are discussed with the available literature.- Anthelmintic Activity of Hiptage benghalensis (L) Kurz Leaves
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Authors
S. V. Chordiya
1,
R. B. Pimprikar
2,
S. B. Yeshwante
2,
Tanvir Shaikh
2,
P. N. Patil
3,
M. K. Kale
4,
B. M. Firke
4
Affiliations
1 Varadvinayak Sankul, Flat No-1, Bajrang Chawk, N-8, CIDCO, Aurangabad-431005, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 Science College, Nagaon, Dhule (M.S.), IN
4 KYDSCT,s College of Pharmacy, Sakegaon, Jalgaon (M.S.), IN
1 Varadvinayak Sankul, Flat No-1, Bajrang Chawk, N-8, CIDCO, Aurangabad-431005, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 Science College, Nagaon, Dhule (M.S.), IN
4 KYDSCT,s College of Pharmacy, Sakegaon, Jalgaon (M.S.), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 234-235Abstract
Worm infestation is one of the major global public health problems, more so in tropical countries. Worms can cause various GI and general symptoms. In addition some of them can cause blood lose, nutritional deficiencies. Helminthiasis is among the most important animal health problems. The disease is highly prevalent particularly in developing countries. In present study Aqueous and ethanolic extract of Hiptage benghalensis (L) kurz, belonging to family Malpighiaceae leaves were investigated for anthelmintic activity. The extracts were used in concertrations of 5, 10 and 25mg/ml and the process involves determination of time of paralysis and time of death of Pheritima posthuma (earth worm). Among the two extracts tested, aqueous extract showed more potent activity against the worm when compared with standard drug Piperazine citrate.Keywords
Anthelmintic, Hiptage Bengalensis, Piperazine Citrate, Aqueous Extract.- Preparation and Evaluation of Anti-Inflammatory Transdermal Drug Delivery System
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Authors
S. M. Sarode
1,
A. R. Bendale
2,
M. Mittal
1,
M. A. Chaudhri
3,
M. K. Kale
3,
G. Vidyasagar
4,
B. Shrivastava
5
Affiliations
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, IN
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, IN
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, IN
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 791-794Abstract
An abundance of the anti-inflammatory drugs are available for use in current medicine which have an established use in the treatment of arthritis and other painful conditions, amongst them one of the novel drug is Aceclofenac. Gels are an excellent formulation for several routes of administration such as oral, topical, nasal, vaginal, and rectal. Gel can be clear formulations when all of the particles completely dissolve in the dispersing medium. But this doesn't occur in all gels, and some are therefore turbid. This need has emphasized the importance of developing a topical dosage form of such drugs.
Aceclofenac is novel non steroidal anti-inflammatory drug which have proven its effectiveness in many of painful diseased conditions like osteoarthritis, rheumatoid arthritis, spondylitis etc. Like other NSAIDs it is also associated with adverse effects, majority of them are of gastrointestinal system (dyspepsia, abdominal pain, nausea and diarrhea). Present study was undertaken to develop an effective and stable topical formulations of Aceclofenac gel.
Keywords
TDDS, Aceclofenac.- Spectrophotometric Methods for Simultaneous Estimation of Rabeprazole and Diclofenac from Combined Tablet Dosage Form
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Authors
Affiliations
1 Kamla Nehru College of Pharmacy, Butibori, Nagpur-441108 (MS), IN
2 Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442001 (MS), IN
3 Anurag College of Pharmacy, Warthi, Bhandara (MS), IN
1 Kamla Nehru College of Pharmacy, Butibori, Nagpur-441108 (MS), IN
2 Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha-442001 (MS), IN
3 Anurag College of Pharmacy, Warthi, Bhandara (MS), IN